Inhalation Toxicity of Indoors Volatile Organic Compounds in Mice / 环境与健康杂志

ABSTRACT

Objective To study the inhalation toxicity of volatile organic compounds in mice. Methods The VOC mixture was prepared according to the monitoring data on indoors air. NIH mices were exposed to the gaseous mixture at the doses of 80.00 mg/m3,64.00 mg/m3,51.28 mg/m3,40.96 mg/m3,32.79 mg/m3 and 26.21 mg/m3 to determine the acute toxicity,and at the doses of 10.75 mg/m3,5.38 mg/m3,2.69 mg/m3 to examine the toxic effect on the weight,organ coefficient,the activity of GSH-Px and SOD and the contents of MDA in the serum. The accumulative toxicity was determined. Results The LD50 of acute inhalation toxicity was 53.74 mg/m3.After exposed to this gaseous mixture for 30 days,the body weight decreased significantly,the organ coefficient of liver and kidney changed,and the activity of GSH-Px and SOD decreased,the contents of MDA in serum increased. The accumulation coefficient was above 5. Conclusion This VOC mixture has weak accumulation toxicity in mice,but have some other toxicity.