Apoptosis and expression of Bcl-2 and Bax in decidua tissue of spontaneous abortion mouse / 中国免疫学杂志
Chinese Journal of Immunology
;
(12)2001.
Article
in Chinese
| WPRIM
| ID: wpr-546538
ABSTRACT
Objective:
To study the pathological mechanism for spontaneous abortion by determining apoptosis and expression of Bcl-2 as well as Bax in decidua tissue of spontaneous abortion models and normal pregnancy mice.Methods:
The abortion-prone CBAXDBA/2 matings were established as the model of spontaneous abortion and the nonabortion-prone CBAXBALB/c matings were used as the model of normal pregnancy.SABC was used to detect the expression of Bcl-2 and Bax in decidua tissue of spontaneous abortion and normal pregnancy at day 13 of gestation.Medical color-image measure system for immune-histochemistry was used for semiquantitative analysis.Apoptosis was detected by in situ TUNEL assay.Results:
In decidua tissue of the spontaneous abortion models, Bcl-2 expression was lower and Bax was higher than it that of normal model (P
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Immunology
Year:
2001
Type:
Article
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