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Treatment Outcomes of Anorectal Melanoma
Journal of the Korean Society of Coloproctology ; : 27-30, 2011.
Article in English | WPRIM | ID: wpr-54673
ABSTRACT

PURPOSE:

An anorectal melanoma (AM) is a very rare tumor. However, sufficient data supporting effective surgical options for the disease do not exist. This retrospective review aimed to analyze treatment outcomes for an AM.

METHODS:

From June 1999 to December 2008, we retrospectively reviewed a prospectively collected consecutive series of 19 patients who had undergone a surgical resection for an AM at a single institute. Surgical method and clinicopathological factors were analyzed.

RESULTS:

The median age was 61.4 years (range, 46 to79 years). Main symptoms were an anal mass, hematochezia, perianal pain, tenesmus, fecal incontinence, and bowel habit change. The average duration of symptoms before diagnosis was 7.8 months (range, 1 to 36 months). S-100 and HMB-45 were positive in all patients, even in non-melanin pigmentation. There were 12 abdominoperineal resections (APRs) and 7 wide local excisions (WEs). The APR showed longer overall survival when compared with the WE (64.1 months vs. 10.9 months, P < 0.001). No patients who underwent a WE survived more than 13 months.

CONCLUSION:

A high index of suspicion is necessary to establish the diagnosis for an AM in patients with anal symptoms, and S-100 and HMB-45 can be useful markers for an AM. Even with the small number of cases and the short follow-up, our data suggest that an APR for an AM may provide longer survival than a WE.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Pigmentation / Prospective Studies / Retrospective Studies / Follow-Up Studies / Fecal Incontinence / Gastrointestinal Hemorrhage / Melanoma Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Journal of the Korean Society of Coloproctology Year: 2011 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pigmentation / Prospective Studies / Retrospective Studies / Follow-Up Studies / Fecal Incontinence / Gastrointestinal Hemorrhage / Melanoma Type of study: Observational study / Prognostic study Limits: Humans Language: English Journal: Journal of the Korean Society of Coloproctology Year: 2011 Type: Article