DERMAL ALLERGY OF GUINEA PIGS DUE TO MOSQUITO BITES / 第二军医大学学报

ABSTRACT

A study under laboratory control was conducted for 3 months to investigate the dynamic changes of local skin reaction and histopathology in guinea pigs exposed to the continuous and repeated bites of mosquitoes (Aedes albopictus)at 1, 6, and 24h after biting.Histopathologically, there were massive cumulations of basophils in the upper dermis of the infected skin, which coincided well with the degree of skin reaction. It would seem reasonable to suggest that hypersensitive guinea pigs show both immediate reaction and cutaneous basophil hypersensitivity.The occurrence of basophils in Skin reaction to mosquito biting, or to other blood-sucking dipterous biting has not previously been reported.