THE RELATIONSHIP BETWEEN LIPOPEROXIDES AND ACUTE LUNG INJURY AFTER SCALD IN RATS / 第二军医大学学报

ABSTRACT

We studied the dynamic changes of pulmonary vascular permeability and lipo-peroxides(LPO) in scalded rats with full-thickness damage (40% of body surface). Both pulmonary vascular permeability and LPO in serum and lung homogenate increasd significantly two hours after scalding. Subsequently interstitial and alveolar edema were developed. Pulmonary vascular permeability was strongly correlated with lung LPO(r = 0.992). Serum CH50 was decreased to 56.8% one hour after scalding, and at the same time leukocyte count increased in the pulmonary interstitium and vasculature.The increases in pulmonary vascular permeability and LPO could be prevented with large doses of vitamine E and leukopenia.The results indicate that the lipoperoxidation of pulmonary vascular endothelial cells secondary to complement activation and pulmonary leukostasis is the major cause of increase jn pulmonary vascular permeability after scalding.