The mechanism and detection of occult hepatitis B infection / 中华疾病控制杂志

ABSTRACT

Low levels of hepatitis B virus(HBV) DNA,viral mutation leading to failure of hepatitis B surface antigen(HBsAg) detection and peripheral blood monouclear cells(PMBC) infected by HBV are the main reasons for occult hepatitis B virus infection(OBI).The host's immune state and HCV infection,schistosoma infection and long-time drinking also play parts in OBI.Until now,there were no uniform way to detect OBI and the standards to judge detection results varied in different studies.Formulating the uniform standards to detect OBI is very necessary to compare the different studies.And further studies were also needed to classify the molecular form about OBI and their relative frequency.