Expression of nitric oxide synthase in the gastric tissues of rats under exposure to infrasound / 西安交通大学学报(医学版)

ABSTRACT

Objective To observe the effects of infrasound on the expression of inducible nitric oxide synthase(iNOS)and endothelial nitric oxide synthase(eNOS)in gastric tissues in rats.Methods The study consisted of a total of 210 SD rats.Of them,140 rats were randomly divided into 8 Hz-90 dB,8 Hz-130 dB and 16 Hz-130 dB experimental groups and a control group A.The experimental groups were exposed to infrasound with different frequencies and intensities,2h/d.After exposure for 1,7,14,21 and 28 days,7 rats randomly selected from each group underwent an examination of the expression of iNOS and eNOS in gastric tissues.The other 70 rats were randomly divided into a control group B and an exposure group continuously stimulated by infrasound with 8 Hz-130 dB for 14 days,2 h/d,and after stopping exposure for 1,7,14,21 and 28 days;the same indexes were detected in 7 rats randomly selected from each group.Results ① Compared with that in the control group A,the expression of iNOS in gastric tissues significantly increased in 8 Hz-90 dB group after exposure for 14 and 21 days,in 8 Hz-130 dB group after exposure for 7,14,21 and 28 days and in 16 Hz-130 dB group after exposure for 7 and 14 days(P