Involvement of Free Radicals in Postischemic Damage of the Gerbil Brains / 第二军医大学学报

ABSTRACT

The effect of bilateral carotid occlusion for 60 min and reperfusion for 30 min on levels of water and lipid peroxides (LPO) and activities of Na+, K+ -ATPase and superoxide dismutase (SOD) in the forebrain was studied in gerbils (Meriones unguiculatus). Luring occlusion, increased water content and decreased activities of Na+, K+-ATPase and SOD were observed. After reperfusion, the activities of Na+, K+ -ATPase and SOD continued decreasing, but LPO elevated apparently. These results support a hypothesis that the free radicals may contribute to the damage of ischemic brain tissue. Pretreatment of gerbils with allopurinol offered protection to cerebral Na+, K+ -ATPase and SOD subsequent to secondary ischemia.