Effect of Noise on the Auditory Center / 第二军医大学学报

ABSTRACT

Adult guinea pigs with normal Preyer's reflexs were used in this experiment and were divided into three groups according to the intensity of noise and exposure time. Auditory brainstem evoked response was recorded before and after exposure to noise. Clicks were presented monaurally at a rate of high (50 Hz) as well as low (10 Hz). The superior olive and inferior colliculus were observed under the electron microscope after the guinea pigs were exposured to 110dB noise for 30 min. The average shift of wave Ⅳ amplitude-intensity function curve was more than that of wave I after exposure to intensive noise. The difference value of wave Ⅴ latency from low (10 Hz) to high (50 Hz) stimulus click rate decreased and was negatively co related with the exposure time. Ⅰ-Ⅴ, Ⅲ -Ⅴ and Ⅳ-Ⅴ interpeak latencies were shorter after exposure to noise. The mitochondria and neurilemma swelling were found in the superior olive and inferior colliculus after exposure. Some mechanisms of the changes of auditory center were discussed in this paper.