THE RELATIONSHIP BETWEEN THERAPEUTIC EFFECT OF“TRIPLEX THERAPY”AND PATHOLOGICAL TYPES IN PRIMARY NEPHROTIC SYNDROME / 解放军医学杂志

ABSTRACT

Fifty cases of primary nephrotic syndrome were studied. There were 40 cases of [type I and 10 cases of type I, all confirmed by renal biopsy. Among them, 17 cases (34%) were mesangial prolife-rativc glomerulonephritis, 12 cases (24%) membranoproliferative glomerulonephritis, 9 cases (18%) proliferative endocapillary glomerulonephritis, 3 cases (6%) membranous nephropathy, 3 cases (6%) minimal change nephrosis, and 6 cases (12%) focal sclerosed glomerulonephritis. 4 to 6-weeks therapy with prednisone, cyclophosphamide and heparin ("triplex therapy") witnessed disappearance of protein-uria in 22 cases, and 44% of the patients showed marked improvement. The total effective rate was 94%. All patients except those with focal sclerosed glomerulonephritis showed favorable response to the treatment. The difference in effectiveness seemed to be related to types and degree of immune injury of the renal pathology.