Role of NF-?B in the mechanism of liver injury following intestinal perforations due to abdominal firearm wound in pigs / 中国现代普通外科进展
Chinese Journal of Current Advances in General Surgery
;
(4)2009.
Article
in Chinese
| WPRIM
| ID: wpr-547833
ABSTRACT
Objective:
To study the role of NF- ?B in the mechanism of liver injury following intestinal perforations due to abdominal firearm wound.Methods:
A total of 42 Chang-Bai piglets were assigned randomly into 7 groups control group and wounded 1, 2, 4, 8, 12, 24 hours group.The model of intestinal perforations due to abdominal firearm wound was established in wounded groups. Hepatic NF-?B and TNF-? content was measured with immunohistochemical staining and image analysis in all groups. Hepatocyte apoptosis indexes and serum ALT levels were also determined at the same time. The alterations of hepatic tissue were observed under light microscope.Results:
Levels of hepatic NF-?B activity in wounded groups were significantly elevated compared with control group, and two peaks appeared in 1 h group and 8 h group, respectively (P
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Current Advances in General Surgery
Year:
2009
Type:
Article
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