THE CHANGE IN EPITHELIUM OF DUODENAL ULCER DURING HEALING PROCESS / 解放军医学杂志

ABSTRACT

25 patients with endoscopy confirmed active duodenal ulcer were treated with Xi Lei San or ci-metidine. Biopsy specimens were taken before and 3 weeks after treatment. Specimens were stained separately with HE, AB (pH2.5), PAS, and AB(pH2.5)/PAS. According to the morphological characteristics, the epithelium was divided into intestinal, gastric and transitional types. The percentage of the length and density of cells of all types were measured. The results were obtained as follows during early phase of healing (3 weeks), goblet cells recovered most markedly in the epithelium close to the lesion. Transitional epithelium could relatively easily be observed.The Xi Lei San and cimetidine produced similar morphological changes. Endoscopically, even after the ulcer was healed, gastric and transitional epithelial cells could still be seen. Hypoplasia was observed in most of epithelial villi.