Effect of intracerebroventricular injection of glutamic acid/MK-801/ketamine on morphine withdrawal syndrome in rats / 西安交通大学学报(医学版)
Journal of Xi'an Jiaotong University(Medical Sciences)
;
(6)1982.
Article
in Chinese
| WPRIM
| ID: wpr-547913
ABSTRACT
Objective To study the relation between the level of central N-methyl-D-aspartate (NMDA) receptor system and the degree of morphine withdrawal syndrome in rats. Methods We established the morphine-dependence model in rats,stimulated addiction by naloxone after intracerebroventricular injection of glutamic acid/ketamine/MK-801,and then observed the effects on rats' morphine withdrawal syndrome. Results Glutamic acid significantly raised the behavior scores of teeth chattering,wet shakes,writhing,penis licking and weight loss,while ketamine and MK-801 decreased the scores. Conclusion Changes of central NMDA system obviously affect morphine withdrawal syndrome in rats,which may be useful laboratory evidence in selecting new no-opiod therapeutic medicine for morphine resistance and addiction.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Journal of Xi'an Jiaotong University(Medical Sciences)
Year:
1982
Type:
Article
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