THE ANTIPLATELET AGGREGATION AND DEAGGREGATION EFFECTS OF AL~(3+) / 第二军医大学学报

ABSTRACT

Al8+ is a newly discovered antiplatelet agent. It was demonstrated that Al3+ inhibited platelet aggregation induced by ADP, arach.idona.te or collagen and also had a deaggregatory effect on platelet aggregates induced by ADP or arachidonate. Both effects were related to the concentration ratio of Ca2+ to Al3+ added.Therefore, it suggests that the antiplatelet effects of Al3+ may be competitive with Ca2+ to the calcium-dependent events in/on platelets. However, the platelet aggregates induced by collagen are not deaggregated by Al3+.So, all the results can clinically be used to explain the gastro-intestinal hemorrhage in the aluminum toxicity and theoretically support the classification of the interplatelet bridges into two kinds: the reversible and irreversible.