DNA Damage in Testicular Cells Induced by Acrylamide through Different Exposure Routes in Mice / 环境与健康杂志
Journal of Environment and Health
;
(12)2007.
Article
in Chinese
| WPRIM
| ID: wpr-548079
ABSTRACT
Objective To know DNA damage effect in testicular cells in mice induced by acrylamide through three exposure routes,intraperitoneal injection,oral exposure and skin exposure.Methods Twenty-four healthy male KM mice were randomly divided into 4 groups,including the blank control group,intraperitoneal injection group,oral exposure group and skin exposure group,6 in each.The exposure dose was 25 mg(/kg?d),for 5 consecutive days,once a day.On the sixth day after the first exposure,the changes of body weight and testis coefficient were observed.The tail length,tail DNA%,tail moment,olive tail moment of testicular cells were detected by single cell gel electrophoresis.Results The body weights of intraperitoneal injection group and oral exposure group decreased significantly (P
Full text:
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Environment and Health
Year:
2007
Type:
Article
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