Effects of Cimetidine with or without Concomitant Vitamin C Intake on Intragastric Milieu / 第三军医大学学报

ABSTRACT

The intragastric changes especially the changes of nitrite level after the cimetidine treatment with or without concomitant administration of vitamin C were studied in 34 patients with peptic ulcer. The pH value, nitrite level, and bacterial count of the gastrie juice after cimetidine treatment were significantly higher than those prior to the treatment (P0.05). Besides,the reduction of BAO,PAO,and MAO was not influenced by vitamin C intake. It is believed that vitamin C can reduce the nitrite concentration which was elevated by cimetidine treatment, but it will not affect the acid-inhibitory function of cumetidine. This fact is of importance for the safe application of cimetidine