Analysis of clinical and pathological features of familial gastric cancer / 中国现代普通外科进展
Chinese Journal of Current Advances in General Surgery
;
(4)2009.
Article
in Chinese
| WPRIM
| ID: wpr-548150
ABSTRACT
Objective:
To explore the clinical and pathological features of familial gastric cancer, and to get the early discovery and early treatment of it.Methods:
Two kindreds of familial gastric cancer were followed up and their clinical and pathological features were analyzed.Results:
Six patients with gastric cancer were found in the 2 kindreds.Autosomal dominant inheritance was observed in these cases.clinical and pathological features of familial gastric cancer were showed according to the documentanalysis:
early onset;poor prognosis;patients suffer simultaneous or metachronous carcinoma;CDH1 germline mutation carriers had higher penetrance;pathologically, tumors are mostly diffuse infiltrative type with lower differentiated degree and earlier metastasis to lymphnodes;in one kindred,the sites of the lesions were relatively consistent.Conclusion:
Familial gastric cancer has particular clinical and pathological featuresearly onset;poor prognosis;patients suffer simultaneous or metachronous carcinoma;CDH1 germline mutation carriers have higher penetrance; pathologically,tumors are mostly diffuse infiltrative type with lower differentiated degree and earlier metastasis to lymphnodes.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Current Advances in General Surgery
Year:
2009
Type:
Article
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