Role of TNF-? in the mechanism of hepatocyte apoptosis induced by intestinal perforations due to abdominal firearm wound / 中国现代普通外科进展
Chinese Journal of Current Advances in General Surgery
;
(4)2009.
Article
in Chinese
| WPRIM
| ID: wpr-548213
ABSTRACT
Objective:
To study the role of TNF-?in the mechanism of hepatocyte apoptosis induced by intestinal perforations due to abdominal firearm wound.Methods:
A total of 42 Chang-Bai piglets were divided randomly into 7 groups control group and wounded 1, 2 , 4, 8, 12, 24 hour groups.The model of intestinal perforations due to abdominal firearm wound were established in wounded groups. Levels of plasma endotoxin were measured using ehromogenic limulus amehoeyte lysate test.Hepatic TNF-? content was measured with immunohistochemical staining and image analysis in all groups. Hepatocyte apoptosis indexes and serum TNF-? levels were determined at the same time.Results:
Levels of plasma endotoxin, serum TNF-?, hepatic TNF-? content and hepatocyte apoptosis indexes in wounded groups were all significantly elevated compared with control group(P
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Prognostic study
Language:
Chinese
Journal:
Chinese Journal of Current Advances in General Surgery
Year:
2009
Type:
Article
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