PATHOLOGICAL STUDY OF NONCIRRHOTIC HEPATOCELLULAR CARCINOMA: ITS ETEOLOGY AND HISTOGENESIS / 第二军医大学学报

ABSTRACT

Observations on 142 cases of noncirrhotic hepatocellular carcinoma (NCH) (135 surgical operating specimens, 8 autopic cases) were made. 50 cases of cirrhotic hepatocellular carcinoma (CH) (42 surgical operating specimens, 8 autopic cases) were taken as the control. The results were as follows(1)In both groups, the hepatocellular carcinoma (HCC) had a similar background of liver diseases. 51.41% of the cases of hepatitis B and 48.59% of the cases of"orcein negative hepatitis" were associated with NCH,while 58.00% of the former and 42.00% of the latter were associated with CH. In both groups in the cases of HCC were included 5 cases of primary multiple carcinoma. We considered that pathogenesis of HCC were synthetic factors. It was assumed that NCH is due to weak carcinogen, hepatic parenchyma is lightly destroyed, and as the human body has hypersusceptibility to HCC, the precancerous stage is short and cancer occurs early.(2)In 80.99% of the NCH cases and 100% of the CH cases was found proliferation of oval cells. The difference between the two groups of HCC was statistically significant.The proliferation may be a repairing reaction. Owing to the action of car-cinosen, the poorly differentiated HCC may be derived from the disturbances of oval cells.(3)In 29.57% of the cases NCH and 70.00% of the cases CH was found hepar tocyte dysplasia, and the difference between the two groups of HCC statistically significant. It was indicated that dysplasia may be precancerous disoders.Oval cell proliferation and hepatocyte dysplasia of the NCH group are less than those of the CH group.It is suggested that liver tissues of the NCH group are slightly damaged, hence the incidence of NCH is lower than that of CH.