Effects of Selenium on Thyroid Function and Deiodinase Activities in EAT Rats / 环境与健康杂志

ABSTRACT

Objective To explore the effects of different levels of selenium nutrition on thyroid function,liver deiodinase type Ⅰ(DⅠ) and brain deiodinase type Ⅱ(DⅡ) activities in experimental autoimmune thyroiditis (EAT) rats. Methods A total of 32 female Lewis rats were randomly divided into four groups that included control group,model group,EAT with selenium-supplementation group and EAT with selenium-deficiency group. After two weeks of the basal diet administration,the rats were fed on forage containing different levels of selenium for nine weeks and the total intake of selenium were 4,4,40 and 0.4 ?g/d,respectively. The rats of model group,EAT with selenium-supplementation group and EAT with selenium-deficiency group were induced to establish the model of experimental autoimmune thyroiditis from the third week to eighth week. The pathological change of thyroid was examined,and the levels of selenium in the blood,serum thyroid autoantibody and thyroid hormone,DⅠ and DⅡ activities were measured simultaneously. Results Compared with control group,thyroid autoantibody and thyroid hormone levels significantly increased in model group,EAT with selenium-supplementation group and EAT with selenium-deficiency group (P