The dynamic expression of Nrf2 and HO-1 in spinal cord tissues of experimental autoimmune encephalomyelitis of rats and the mechanism underlying neuroprotective effect of edaravone / 中国免疫学杂志
Chinese Journal of Immunology
;
(12)1985.
Article
in Chinese
| WPRIM
| ID: wpr-548763
ABSTRACT
Objective:
To study the effect of edaravone on EAE rats and the underlying mechanism.Methods:
Wistar rats were immunized with GPSCH,and randomly divided into control group,EAE group,dexamethasone group,low dose of edaravone group and high dose of edaravone group.The morbidity of disease and clinical signs were observed.The pathological changes of spinal cord tissue sections were observed under light microscopy after HE staining and trichrome staining.The expression of Nrf2 and HO-1 was observed by immunohistochemistry.Results:
Morbidity of high dose of edaravone group (8.33%) and DXM group (0%) was significantly lower than in EAE group (58.3%) (P
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Immunology
Year:
1985
Type:
Article
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