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Effects of ouabain on Na~+-K~+-ATPase activity and the expression of dopamine D_1 receptor in rat kidney cortex / 西安交通大学学报(医学版)
Journal of Xi'an Jiaotong University(Medical Sciences) ; (6)1982.
Article in Chinese | WPRIM | ID: wpr-548802
ABSTRACT
Objective To study the effects of chronic ouabain treatment on Na+-K+-ATPase activity and the expression of dopamine D1 receptor in rat kidney cortex. Methods A total of 28 male Sprague-Dawley (SD) rats were randomly divided into ouabain group and control group,which were treated with ouabain or saline for 5 weeks; rat tail systolic blood pressure (SBP) was recorded weekly. Rats were sacrificed after 3 and 5 weeks,respectively. Then Na+-K+-ATPase activity and the expression of dopamine D1 receptor in rat kidney cortex were measured by colorimetric assay and real-time PCR,respectively. Results After 3 weeks of ouabain treatment,the mean SBP did not change significantly,but the Na+-K+-ATPase activity increased (P

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Xi'an Jiaotong University(Medical Sciences) Year: 1982 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Journal of Xi'an Jiaotong University(Medical Sciences) Year: 1982 Type: Article