A STUDY ON THE ACTIVE PRINCIPLE OF POLYALTHIA NEMORALIS II. THE SYNTHESIS OF NATURAL OCCURRING METALLIC COMPOUND ZINCPOLYANEMINE / 第二军医大学学报

ABSTRACT

Zincpolyanemine, which has been isolated from the root of polyalthia nemoralis A. et DC.exhibiting antimalarial activity against Plasmodium berghei, is a natural occurring metallic compound. Its chemical structure has been determined as the zinc salt of 2-mercaptopyridine N-oxide by means of synthesizing by five steps starting with 2-aminopyridine. The mp, IR and HMR spectra of the synthetic product coincide with those of the natural zincpolyanemine.