Histological Criteria for Differentiation between Lymphofollicular Tumor-like Hyperplasia and Follicular Lymphoma / 第三军医大学学报

ABSTRACT

The histological features of 22 cases of lymphofollicular tumor-like hyperpla-sia and 16 cases of follicular lymphoma were reviewed in order to find out certain criteria to differentiate the former from the latter. It was suggested that an integral consideration of the pleomorphism and the relative monomorphism of the cells of which a follicle consists, the presence or absence of the tingible body macrophages, and the presence or absence of the mantle zone of the small lymphocytes should be imperative in the differentiation of follicular hyperplasia from follicular lyrnphoma. Other signs such as the back to back position of the follicular follicles is of little significance in the differentiation since it is a normal phenomenon of the growth and enlargement of follicles.