Experimental Study of Early Intravenous Fluid Infusion in Dogs with Combined Burn-Blast Injuries / 第三军医大学学报

ABSTRACT

How to use intravenous fluid therapy safely in patients with combined burn-blast injuries is an unsolved problem. Therefore, this experimental study was carried out in 64 dogs with combined injuries of 40% second degree burns (inflicted with nalpam) and moderate or severe blast injury (inflicted with TNT charge explosion) . Intravenous infusion was administered as early as 6-8 hours after injury. The amount was 0.5 ml colloid and 1-1.5 ml crystal solution/kg of body weight/one percent of body surface burns in the first 24 hours after injury, and a half of this amount was given in the second 24 hours. The transfusion of the fluid was finished within 3-5 hours. Another amount 30% of the total amount of the fluid intravenously infused was added as drinking water.It was found that there was no significant difference between the infused animals and the controls so far as the pulmonary pathological changes (including pulmonary edema) were concerned. It is believed that a reasonable amount of intravenous fluid can be safely given to patients with combined burn-blast injuries provided that the changes of the urinary output and the physical signs of the chest are carefully monitored.