RCR AND ADP/O RATIO CHANGES OF RAT LIVER MITOCHONDRIA DURING EARLY PHASE OF BURN INJURY / 第二军医大学学报

ABSTRACT

Using succinate as a substrate,the respiratory control ratio (RCR) of liver mito-chondria of 20 burned Sprague-Dawley rats (male, 20%of burned body surface area, III degree burn), and 32 burned Wistar rats (male), increased 30 minutes and 2 hours after burn, and ADP/O ratio increased 39 minutes after burn. But ADP/O ratio decreased and RCR was nearly normal 4 hours after burn.The observations suggest that there is an increasing mitochondria coupling during the early phase of burn injury, which has not been reported.