STUDY ON CLINICAL PHARMACOKINETICS OF THE NEW PHO- TOSENSITSZER PHOTOCARCINORIN FOR TUMOR LOCALIZATION AND PHOTORADIATION THERAPY / 第二军医大学学报

ABSTRACT

The clinical pharmacokinetic behavior of new photosensitizer photocarcinorin for the photoradiation therapy of 11 patients with different malignant tumors was studied by means of fluorospectrophotometric method after intravenous infusion.The dose infused was 4-4.5 mg/kg body weight and the infusion rate, 0.1 mg/ kg/min.It is a three-compartment model as determined by the drug-time curve through Akaike's Information Criterion(AIC) .The principal pharmacokinetic parameters calculated by nonlinear least-square regression program are t1/2? = 0.26?0.05h, t1/2? = 4.52?1.04h, t1/2?=32.9?5.31h.In addition, the pharmacokinetic parameters of one patient injected with lower dose(1.82 mg/kg)were also determined, and shown as a three compartment model.