A Clinical Study of Plasma Fibronectin in the Patients with Severe Viral Hepatitis / 第三军医大学学报

ABSTRACT

Plasma fibronectin (PFn) was determined serially by both simple radial immunodiffusion (RID) and improved indirect hemoagglutination test (using gelatin-coated sheep RBC) in the serum of 30 patients with severe viral hepatitis (SVH),100 normal subjects,and 30 patients with chronic active hepatitis (CAH).Liver function,serum C3 and immunoglobulin (Ig) were determined simultaneously.Endotoxin was assayed by Limulus lysate test in 21 patients with SVH.The normal value of PFn was 284.31?45.56?g/ml and 130.64 (geometrical mean).The PFn level significantly decreased in patients with SVH.Significant correlations were found between PFn levels and the values of total serum bilirubin,prothrombin time,C3 and IgM.Low PFn levels were remarkably associated with the occurrence of endotoxeamia.Serial determinations of PFn in serum can reflect the severity of the illness and prognosis in the patients with SVH.