ANTIPLATELET EFFECTS OF PILOCARPINE / 第二军医大学学报

ABSTRACT

After the antiaggregatory effect of pilocarpine on platelets was discovered, we continued to demonstrate its other effects on platelets. The results of the experiments with rabbit platelets were as follows. (1)Pilocarpine inhibited platelet aggregation and ATP secretion induced by ADP, arachidonate and collagen; it inhibited platelet shape change induced by collagen, but not by ADP and arachidonate. (2)Pilocarpine deaggregated the platelet aggregates induced by ADP and arachidonate, but had no such effect on those induced by collagen. The interplatelet bridge demonstrated by Nachman et al can not reasonably explain the latter phenomenon, we suggest two hypothetical models of interplatelet bridge with glycoprotein G(GPG)as a component.