EFFECTS OF DAURICINE ON THE TOLERANCE TO ANOXIA IN MICE AND EXPERIMENTAL MYOCARDIAL ISCHEMIA AND INFARCT / 中国药理学通报

ABSTRACT

The effects of dauricine on tolerance to anoxia in mice and on experimental myocardial ischemia and infarct in rats were investigated .Dauricine was found to be capable of increasing the tolerance of mice to anoxia and prolonging life and decreasing oxygen consump-sion.Dauricine improved the ECG L-Ⅱ "J" point change induced by pituitrin and LAD ligation, and reduced the rate of the development of pathologic Q wave and the infarct size induced by LAD ligation as indicated by N-BT staining in rats. The results suggest that dauricine offered beneficial effect on the experimental ischemia and infarct. Dauricine; Propranolol; Verapamil; Nifedipine; Pituitrin; ECG; Myocardial infarct