Platelet Aggregation in Patients with Severe Viral Hepatitis / 第三军医大学学报

ABSTRACT

Platelet aggregation ratio (PAR) was assessed in 35 patients with severe viral hepatitis (SVH) with Born's method.The PAR of normal individuals,patients with acute icteric hepatitis,and those with chronic active hepatitis were also studied to serve as controls.It was found that PAR decreased markedly in SVH patients,which was marked in the early stage of SVH,more marked in the intermediate stage,and most marked in the late stage.The changes of PAR were in negative correlation with those of serum total bilirubin,and in positive correlation with those of prothrombin activity.The reduction of PAR in SVH patients might be ascribed to the defect of platelets themselves as revealed by cross-over experiments.The results of this study indicate that PAR may be useful in judging the severity of SVH patients since the degree of PAR reduction parallels closely with the severity of liver damage.Finally the conditions of platelets in vivo and in vitro in SVH were discussed.