Some Special Problems concerning Idiopathic Hypoparatbyroidism / 第三军医大学学报

ABSTRACT

There have been more than 100 cases of idiopathic hypoparathyroidism(IHP) reported in our country. The 8 cases reported in this paper showed some special features in the clinical manifestations, the biochemical parameters, and the response to treatment.Clinical, one case was complicated with Klinefelter's syndrome. Another case suffered from subcorneal pustulosis prior to the onset of idiopathic hypo-parathyroidism. Two cases were misdiagnosed as epilepsy and admitted to the department of neurology. Generalized exfoliative dermatitis was induced in one case by large doses of antiepileptic agents to control the convulsive seizures.Biochemically, both CPK and LDH were elevated in one case. Serum calcium was as low as 2.4 mg/dl in one case, and serum phosphrus was as high as 11.7 mg/d1 in another. These phenomena were rarely encounted in IHP.Therapeutically, transplantation of homogenous parathyroid gland with blood vessels was the method of choice. Two cases were treated in this way with good results. A third case received a dog's parathyroid gland, which also showed good results. The mechanism of heterogenous parathyroid transplantation needs further investigation.In addition, the diagnosis and differential diagnosis of IHP were discussed.