EFFECTS OF PHLOROGLUCINOLS FROM DRYOPTERIA CRASSIRHIZOMA NAKAI ON ULTRASTRUCTURE AND RESPIRATION IN LEUKEMIA P388 CELLS / 中国药理学通报

ABSTRACT

Phloroglucinol is an antineoplastic effective compound from Dryopteria Crassirhizoma Nakai. In this study, mice implanted with leukemia P388 were examined under an electron microscope. It' was found that the leukemia bearing mice, which had been injected with phloroglucinol exhibited degeneration and swelling of mitochondria in the P38'8 cells. Measurement with an oxygen electrode showed that the drug treatment of P388 cells markedly lowered their oxygen consumption in comparison with the control cells .The results demonstrate that phloroglucinol inhibits respiration of tumor cells. Probably, the mitochondria of tumor cells is a target that the drug attacks.