THE EFFECTS OF ACTINIDIA CHINENSIS PLANCH ON THE PREVENTION OF CANCER IV. The Blocking Effects of Concentrated Juice on theN-nitroso Ethyl Urea (NEU) in Vivo——RatEmbryotoxicity Test / 营养学报

ABSTRACT

In order to observe the effect of Actinidia chinensis Planch fruit juice on blocking the formation of N-nitrosamide in vivo, 99 pregnant Wistar rats were divided into five groups. The rats of each group were orally given ni-trosamide precursor ethylurea (0.25, 0.50, 1.00, 2.00 4.00 mmol/kg) and NaNO2 (0.125, 0.25, 0.50, 1.00, 2.00 mmol/kg) respectively once a day for three days, on the 7th, 8th and 9th day of pregnancy. Half of the rats in. each group were administrated two precursors and a 4% starch solution, while the other half were administrated two precursors and the tested fruit juice.In the groups without the juice, NEU was formed in vivo, which led to a high mortality of embryos. The embryolethality was 5.21%, 43.66%, 71.7%, 85.8% and 100% respectively, and 4 pregnant rats died in the highest dosage group. However, the rats who received both the two precursors and the tested fruit juice, the living embryos and embryolethality were similar to the control groups except the highest dosage group. The none treatment group and groups only given one of the precursors were done as control groups. The results suggested that the concentrated juice could block the formation of NEU in vivo and prevent the embryotoxicity of NEU.