INFLUENCE OF DEFIBRINOGENASE ON EXPERIMENTAL DISSEMINATED INTRAVASCULAR COAGULATION ( DIC) IN RATS / 中国药理学通报

ABSTRACT

Experimental DIC model was performed by infusion of thrombin and PAMBA. The rate of glomerular microthrombosis was declined from 56% of the control group to 26% of the treated 2h after venous injection of defibrinogenase. The reduction of pletelet count of the treated group (7.9 ?1.17) was more less than the control ( 3.1? 1.44). There was a trece content in plasma fibrinogen 1h after giv ing drug.It was a significant difference bet-ween the treated and control group (P