EFFECT OF DAURICINE ON LEVEL OF TXA_2 AND cAMP IN THE PLATELET / 中国药理学通报

ABSTRACT

The effect of dauricine on level of TXA2 and cAMP in the rabbi platan-elet was studied. The results showed that dauricine protected signific-tly mice against the sudden death induced by intravenous arachidonic acid in vivo, and that dauricine inhibited the platelet aggregation ind uced by arachi- donic acid, inhibited the production of TXA2 in the plateletand did not change the basic cAMP level in the platelet invitro. These suggested that one of the action mechanism of the inhibition of the platelet aggregation by dauricine was possibly related to the inhibition of the production of TXA2.