EFFECTS OF ARMILLARIELLA MELLEA POLYSACCHARIDE ON IMMUNOLOGCAL FUNCTION IN MICE / 中国药理学通报

ABSTRACT

Armillariella mellea polysaccharide ( AP ) was isolated from solid fermented Armillariella mellea. AP ( 100 mg/kg?d, ig ? 5 d ) increased the production of serum hemolysin in normal mice as well as in im-munodepressed mice induced by cyclophosphamide. At the dose of 50 mg/kg?d ig?5d, AP also caused a significant increase of spleen plaque forming cells ( PFC ) in normal mice. AP ( 10, 50?g/ml ) markedly enhanced Con A-induced lymphocyte proliferation of mouse spleen cells in vitro, but it had no potentiating effect on delayed cutaneous hypersensitivity ( DCH ) to 2,4-dinitrochlorobenzene ( DNCB ) in normal mice. AP ( 100 mg/kg/d, sc? 7d) increased both clearance rate of iv charcoal particles and phagocytic activity of ma-crophages of abdominal cavity in normal mice.