EFFECT OF CORYDALIS AMABILIS MIGO TOTAL ALKALOID ON FUNCTION OF PLATELETS IN RATS / 中国药理学通报

ABSTRACT

Corydalis amabilis Migo total alkaloid (COAMTA) given in vitro or in vivo caused an inhibition on ADP-induced blood platelet aggregation. In vitro, COAMTA 15.6, 31.3 & 62.5 ?g/ml PRP showed their inhibitory rates of 8.2, 32.0, & 36.8%. In vivo, at 10, 20, 40 min after iv COAMTA ( 0.6 mg/kg ) , the rates of inhibition were 40, 62.8, 24%.The thrombi formed in vitro were measured also. The results showed that COAMTA given in vitro or in vivo reduced the length and weight of thrombus, at same time, reduced rat platelet adhesion.A carotid-jugular extracorporeal shunt was made in the rats. A 6cm length of silk thread was placed in the shunt. 15 min after the restoration of blood flow in the shunt, the Wet weight of thrombus developed on the thread was measured.The thrombus weight was significantly reduced when COAMTA was given iv 0.3, & 0.6 mg/kg, im 0.9 mg/kg & po 1.5 mg/kg. The thrombus weight of control group was 26.1?0.7, but that of the medicated group was 8.9?1.7, 18.0?1.3, 16.4?0,6 a & 19.7?0.7 mg. The inhibitory rates were 66.1, 31.3, 37.2, & 28.4%.