RAD1OIMMUNOASSAY FOR TXA2 AND PGi IN EXPERIMENTAL INVESTIGATIONS ON THROMBOSIS / 解放军医学杂志

ABSTRACT

TxB2 and 6-keto-PGF1 alpha were determined in healthy persons, and their concentrations in plasma were 127?48 pg/ml(n = 40) and 138?77.9pg/ml(n = 36), respectively. We found that 6-keto-PG-F1 alpha levels in 156 specimens of the normal endomctriums elevated during secretive period, and the TxB2 also increased markedly during the menstrual period. Experimental DIC was induced by constant infusion of thrombin and EACA into the ear vein of the rabbits, and TxB2 and 6-keto-PGF1 alpha levels were increased at once in such instances. In 14 cases undergoing extracorporeal circulation, TxB2 was obviously enhanced during bypass and reached a peak value at 10 minutes of bypass, and then returned to the preopcrative level 2-4 hours after bypass, but there were no remarkable changes in 6-keto-PGF, alpha levels during bypass. The experimental results were discussed in the paper.