Ultrastructural changes in rat lung with blast injury / 第三军医大学学报

ABSTRACT

The experimental blast lung injuries are as follows 1.permiability of the alveolar epithclium(AE),capillary endothelium(CE) and their intercellular junctions increased; 2.small vacuoles,large vacuoles formation and cell membrane damage in the AE and CE increased in amounts; 3.blood platelets aggregated and neutrophils trapped in the capillary lumen.These changes are more serious in the CE and especially 72 h after trinitrotoluene(TNT)explosions.These suggest that the CE is more sensitive to blast injury than AE,and the CE damage may be related to the neutrophils trapping and platelets aggregation in the capillary lumens.