TONIC INHIBITION OF RAT SERUM PHCSPHOLIPASE A_2 BY GLUCOCORTICOIDS / 第二军医大学学报

ABSTRACT

Phospholipase A2(PLA2) activity in rat serum and honiogenate of liver and lungs was determined by the method of titrating.It was found that serum PLAi activity of adrenalectornized rats(ADX) was 75.13 + 7.94 U, which was significantly different from that of control rats (58.88 ?15.33U).When ADX were injected with hydrocortisone(5 mg/100g tody weight) and decapitated 2h later, the serum FLA2 activity was 55.09?8.63U, which did not differ significantly from that of controls.However, the PLAi activity in the homogenate of lungs and.liver had no significant change.These results show that glucocorticoids exerted tonic inhibition of rat serum PLA2.