The Effect of Sulmazole on Beating Rate of Cultured Cardiomyocytes / 第二军医大学学报

ABSTRACT

The effects of sulmazole and isoprenaline on beating rate of cultured neonatal rat ventricular cardiomyocytes were measured with electrooptical technique. The results showed (1) The spontaneous beating rate of primary cultured cardiomyocytes (culture for 72 h, 37?0.5℃, pH 7.2) was 134?16 beats/min (x?SD, n =41) and remained constant within 120 min. (2) The effect of sulmazole on beating rate was similar to that of isoprenaline. They both produced an apparent positive chronotropic action in a dose - dependent manner within a certain concentration range. The maximal responses between them were not statistical different.