The Effect of Sulmazole on Beating Rate of Cultured Cardiomyocytes / 第二军医大学学报

ABSTRACT

The effects of sulmazole and isoprenaline on beating rate of cultured neonatal rat ventricular cardiomyocytes were measured with electrooptical technique. The results showed: (1) The spontaneous beating rate of primary cultured cardiomyocytes (culture for 72 h, 37?0.5℃, pH 7.2) was 134?16 beats/min (x?SD, n =41) and remained constant within 120 min. (2) The effect of sulmazole on beating rate was similar to that of isoprenaline. They both produced an apparent positive chronotropic action in a dose - dependent manner within a certain concentration range. The maximal responses between them were not statistical different.