STUDY ON THE MECHANISM OF RELAXATION OF BERBAMINE ON THE ISOLATED RABBIT RENAL ARTERIES / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12)1986.
Article
in Chinese
| WPRIM
| ID: wpr-550091
ABSTRACT
The contraction of the isolated rabbit renal arteries induced by noradrenaline, high K+ & calcium could be relaxed by berbamine ( BA ). BA shifted dose-response curve of noradrenaline, high K+ snd calcium to the right, but the maximal response was reduced. The antagonistic parameter pD' 2 of berbamine on calcium contrac-tion was 4.76, which is similar to the verapamil (pD'2=5.68). Therefore berbamine can be considered as a non-competitive calcium antagonist.
Full text:
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Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmacological Bulletin
Year:
1986
Type:
Article
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