ANTIINFLAMMATORY, ANALGESIC & ANTICANCER EFFECTS OF FERULOFEN / 中国药理学通报

ABSTRACT

Antiinf lammatory effects of Ferulofen ( FL ) were shown by im or ip on xylene-induced swellingof mice ear, carrageenin produced edema of hind paw in rats, and decreased volume of pleural exud- ate on carrageenin-induced acute pleurisy of rats, FL also inhibi-tied the proliferating granuloma by croton oil. The above dose r-ange in 50-100mg/kg im or ip which presented a good dose-effect relationship, FL also inhibited the mice writhing caused by H AC & tail-flick response to 1 light irradiation, suggesting its strong analgesic effect. In addition, its anticancer effect in vitro ( carcinoma of Ehlrich ascitis)was better than that in vivo ( Sl80 sarcoma) in mouse. So FL may be considered to be a promising new type of non-steroidal antiinflammatory & anticancer drug ,worthy of further reseaching & exploring in the future.