Mechanisms of the Decrease of Glucocorticoid Receptor in Rat Hepatic Cyto sol after Scalding: Studies on Partial Adrenalectomized Rats / 第二军医大学学报

ABSTRACT

There was no significant increase of serum glucocorticoid in partial adrenalectomized rats after scalding, whereas glucocorticoid receptor in hepatic cytosol of those rats tended to increase. And 6 h after scalding, the difference between scalded and controlled rats was highly significant. Hepatic glucocorticoid receptor mRNA was also determined by the method of dot blot. It was found that hepatic gluco corticoid receptor mRNA of partial adrenalectomized rats was increased 6h after scalding. Those results suggest that the decrease of hepatic cytosol glucocorticoid receptor in scalded intact rats was dependent on the rise of serum glucocorticoid.