EFFECT OF 3, 6-DIMETHAMIDODIBENZOPYRIODONIUM CITRATE ( IHC-65 ) ON PLATELET FUNCTION AND cAMP LEVEL IN RABBITS / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12)1987.
Article
in Chinese
| WPRIM
| ID: wpr-550225
ABSTRACT
IHC-65 was found to be a potent inhibitor of platelet function . It inhibited platelet aggregation induced by threshold concentration of ADP, arachidonic acid and collagen with dose-dependent manner in vitro, and at 96?mol/L, AIR ( aggregation inhibition rate,) were 71.56, 66.93 and 68.47% respectively. IHC-65 inhibited platelet serotonin release induced by collagen,and at 96 ?mol/L, release inhibition rate was 82.97%. IHC-65 did not influence cAMP level in platelet significantly. It is concluded that IHC-65 inhibited platelet aggregation and its action mechanism may be related to inhibition of serotonin release and to antagonizing Ca ++ .
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmacological Bulletin
Year:
1987
Type:
Article
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