MECHANISM OF IMMUNOMODULATORY ACTIONS OF TOTAL GLUCOSIDES OF PAEONY IN MICE / 中国药理学通报
Chinese Pharmacological Bulletin
;
(12)1986.
Article
in Chinese
| WPRIM
| ID: wpr-550333
ABSTRACT
Mechanism of Immunomodulatory actions of total glucosides of paeony ( TGP ) was studied by McAb indirect immunofluorescence. TGP 5 mg/( kg?d ) ip for 8d suppressed DTH, that was enhanced by cyclophosphamide( Cy), and decreased L3T4+/Lyt-2+ 〔 (Th/i)/(Ts /c) 〕 cell ratio in ICR mice .TGP 5 mg/ ( kg?d ) ip for 5d enhanced DTH that was suppressed by Cy, and increased the L3T4+/Lyt-2 + cell ratio in ICR mice. The same dose of TGP ip for 5d promoted the hemolysin production of spleen cells, that was suppressed by Cy, increased the L3T4+/Lyt-2 + cell ratio in BLAB/c mice. The results suggest that immunomodulatory actions of TGP might be brought about by altering Th/Ts cell ratio.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Pharmacological Bulletin
Year:
1986
Type:
Article
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