Effects of TRH on Lipid Peroxidation in Spinal Cord Injury in Rat / 第三军医大学学报

ABSTRACT

The effects of thyrotropin releasing hormone (TRH) on lipid peroxidation in spinal cord injury in rats were studied. It was found that TRH (0.2 mg/kg, 0.6mg/kg, 2.0mg/kg bolus, followed by the same doses/h over 4 h, iv) could inhibit lipid peroxidation of the injuried spinal cord, decrease malondialdehyde (MDA)production and significantly increase superoxide dismutase (SOD) activity in a dose-dependent manner. The results indicate that the antioxidant effects of TRH are the result of increase of SOD activity. TRH might be an effective free radical scavenger.