Significance of Determination of Serum Apolipoprotein A-Ⅰ and B in Patients with Cerebral Thrombosis / 第二军医大学学报

ABSTRACT

Serum apolipoprotein (Apo A-Ⅰ and Apo B) and lipid (Total cholesterol Tch, Triglyceride TG and HDL cholesterol HDL-C) levels were measured in 64 patients with cerebral thrombosis and 56 healthy controls. Apo A-Ⅰ and Apo B were determined by a rate immunonephelometric assay. Apo A-Ⅰ and Apo A-Ⅰ /Apo B and LDL-C/Apo B were lower; TG and HDL/Apo A-Ⅰ were higher in patients. Stepwise discriminant analysis showed that Apo A-Ⅰ was the best discriminator. The results suggest that not only the quantitative abnormalities of lipids but also the compositional abnormalities of HDL and LDL particles are existent in cerebral thrombosis; determining the serum levels of apolipoproteins may be more useful than those of lipids.