Observation of Lectin Receptors in Normal Nasal Mucosa, Nasal Polyp, Inverted Papilloma and Papillary Adenocarcinoma / 第二军医大学学报

ABSTRACT

Formalin-fixed paraffin-embedded biopsy specimens of the normal nasal mucosa,nasal polyps, inverted papillomas and papillary adenocarcinomas were analyzed by Avidin Biotin-Peroxidase Complextechnique for the demonstration of lectin receptors including peanut agglutinin (PNA), concanavalin ensifomis agglutinin (ConA),ulex europeaus agglutinin-I (UEA-1), sophora japonica agglutinin (SJA), wheat germ agglutinin (WGA), pisum sativum agglutinin (PSA), carcinoembryonic antigen (CEA) and keratin.lt was found that the distribution of PNA and UEA-I receptors was related to the degree of differentiation, dysplasia or malignant transformation of the nasal mucosa. The quantity of ConA receptors was increased with the degree of transformation of the nasal mucosal cells. There were many kinds of lectin receptors on the surface of one kind of cells. Lectin histochemistry was more economical, convenient, rapid and sensitive than immunohistochemistry. So, lectin histochemistry can be used to examine the degree of differentiation, dysplasia and malignant transformation of nasal neoplastic cells, providing objective index for clinical diagnosis, treatment and prognosis.